I take 1000 mg of Tylenol in the AM and PM and sometimes around 3 PM. This is for generalized pain. I think it is due to PMR. The pain I have is not joint pain, but pain around the joints, I think in the tendons or possibly the muscles. Without Tylenol before I go to bed, I would have a hard time sleeping. Tylenol the rest of the day just cuts the pain in the tendons around the joints. I have had PMR for 35 years with pain throughout the shoulder girdle and hip girdle for no reason, and have been on and off prednisone all that time, mostly on. I am currently on Kevzara for about 9 months and down to 2.5 mg of prednisone. The Kevzara seems to be helping. It does require regular blood tests.