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ADT and Castrate Resistance

Prostate Cancer | Last Active: Sep 29 4:32pm | Replies (31)

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Profile picture for jeff Marchi @jeffmarc

I think you are worrying about the wrong thing. I’ve had PC for 15 years and I’ve Been castrate resistant for six years. I’ve had four reoccurrences but have not had one for four years. I’ve been undetectable for the last 19 months.

I know a lot of other people who are castrate resistant and have been around for decades.

The longer you stay on ADT the more likely it is that you will become castrate resistant. The average is 2 to 3 years, but some people can go up to nine years.

You have been undetectable a long time,I have heard from doctors who recommended others stop ADT In similar situations. If you decide to follow your doctors Advice you could get PSA tests every month to make sure that if your PSA starts rising, you can immediately get back on ADT. There are an awful lot of people who do this. Over at the weekly advanced prostate cancer meeting at Ancan.org There are a few people that have done that With cases similar to yours.

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Replies to "I think you are worrying about the wrong thing. I’ve had PC for 15 years and..."

I have followed your posts closely since my joining this forum. I greatly appreciate your experienced opinions. My Drs have just discontinued my prescription for Orgovyx-- so I guess I'm stopping.

I'm scared- fearful that my PSA will start to rise. But, I'll trust the Drs and we'll see how it goes.

My cancer was stage 4a, Gleason 9, Decipher .99 and I've been told since Day 1 that it's aggressive. So, I don't understand the reasoning for coming off ADT. Seems to me the side effects are worth taking vs my cancer increasing. But, we'll see what happens now.