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K2 supplements mk4 or mk7 or combination?

Osteoporosis & Bone Health | Last Active: Dec 17, 2025 | Replies (39)

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Profile picture for njx58 @njx58

A 2020 study found no additional benefit of 45mg vs. 5mg.
https://profiles.wustl.edu/en/publications/maximal-dose-response-of-vitamin-k2-menaquinone-4-on-undercarboxy
This study found that evidence for MK7 benefits is extremely limited.
https://academic.oup.com/ndt/article/38/10/2105/7190649
As for the book you mentioned, I've never seen so many one-star reviews on Amazon- including several from physicians.

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Replies to "A 2020 study found no additional benefit of 45mg vs. 5mg. https://profiles.wustl.edu/en/publications/maximal-dose-response-of-vitamin-k2-menaquinone-4-on-undercarboxy This study found that..."

@njx58
I doubt if any physicians would give any stars to books on osteoporosis treatment with K2. They would be prescribing bisphosphonates, etc... as my Dr. does. I don't follow that advice as I don't want disintegrating jawbone, femur snapping, etc... awful side effects that result in poor quality bone.