I'm sorry you are experiencing this. Itchiness is misery. I suddenly developed a big itchy rash on both shins after my 7th Taxol infusion. I thought at first it was some kind of bug bites, then maybe poison ivy? It looks like poison ivy, but I haven't been anywhere near that. So I think it's Taxol caused. What helps me is simply Hydrocortisone OTC cream (1%) --oh, and trying so hard not to scratch. And I tried a Benedryl last night before bed. Good luck!!