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Prolia vs. Evenity

Osteoporosis & Bone Health | Last Active: Sep 11, 2025 | Replies (56)

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Profile picture for sungaltoo @sungaltoo

I tried Boniva, a biophosphonate in my 40s when I had osteopenia. I had too much bone pain right away so I stopped. 25 years later I’m at the end of the osteoporosis scale, so I got approved for Evenity. My dr said it was the only drug class that both tore down old bone and rebuilt new bone, and that’s what I needed. After a year I had good results.

Then she said I needed a maintenance drug so I didn’t lose my gains. Since I didn’t tolerate a different biophosphonate, Prolia was a good choice as I could take it the rest of my life, once every 6 months. Reclast was one shot a year for 2-3 years only, with a little more side effects. But I had a lot of bone loss and that probably wouldn’t be enough since I’m young, I’d end up on Prolia anyway. She said Prolia was studied more than a lot of the older drugs, and thought I’d do well on it with my other medical conditions. I have the autoimmune disease generalized Myasthenia Gravis, a seizure disorder, neuropathy and some other minor ones. I’m 5’1” 121 lbs and the regular doses were fine on me for both Evenity and Prolia. I’ve had no side effects except a slight sore arm which I rested a day. The only time I had a little flushing was when the syringe wasn’t brought to room temp first.

I always felt nervous considering a new med, but I’ve done my research, talked to my drs, pharmacist and a lot of people online, slept on it, did some more research, and made my decision. I can honestly say I don’t feel bad about any of the choices I’ve made, because I followed this process, and that’s about as good as it’s going to get

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Replies to "I tried Boniva, a biophosphonate in my 40s when I had osteopenia. I had too much..."

Thanks much for your information, @sungaltoo. I'm glad to hear your choices have worked well for you, and I'm wishing you all the best!