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Adverse Heart conditions from Hormone therapy
Prostate Cancer | Last Active: Jul 4 11:49am | Replies (23)Comment receiving replies
My husband , Gleason 9. PSA 46.6, did Zytiga /prednisone for 12 months and Orgovyx 18 months.
During that time he developed unstable BP, an aortic root aneurysm grew and he developed moderate to severe aortic valve regurgitation.
He is now scheduled for open heart surgery in August at Mayo, to have the aortic valve replaced and the aneurysm repaired.
Pretty sure the ADT made things worse
Replies to "My husband , Gleason 9. PSA 46.6, did Zytiga /prednisone for 12 months and Orgovyx 18..."
While ADT could’ve made things worse, Zytiga was almost definitely the culprit here. I was on ADT for 2 1/2 years and had no problems at all with blood pressure. I know many other people on ADT without any issues with blood pressure.
I know a lot of people on zytiga, many have high blood pressure as a result, Including me. Zytiga caused Me to have four Afib Events, The third one putting me in the hospital for four days with a pulse of 175 if I stood up. Also caused a lot of skipped beats. I quit Zytiga two years ago and my blood pressure has stabilized and I no longer have afib problems doing the same thing that caused Afib when I was on Zytiga.
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It may have been the ADT (Orgovyx) or it may have been the ARPI (Zytiga: Abiraterone).
Of the ADTs tested, Orgovyx was demonstrated to have the least chance of cardiac issues (though the risk was not zero).
Cardiac issues are also a known (but, again small) side-effect of Zytiga. (See attached chart.)