"Your chances are much higher of getting castrate resistant PCa if you take it continuously."
I don't think the research has established that (yet), but it is a solid hypothesis. The thing is, there are basically three options:
1. if the cancer's not progressing, it's not progressing, regardless of what you're taking.
2. if it is progressing and you take ADT to shut down the castrate-sensitive cells, then the tiny minority of cells (if any) that are castrate-resistant may keep multiplying and eventually become dominant (though ARSIs like the -lutamides can postpone that, sometimes indefinitely)
3. if it is progressing and you *don't* take ADT, then the castrate-sensitive cells will remain dominant, but they'll still keep spreading because you're not doing anything to shut them down.
Neither option 2 nor 3 sounds great, but if option 2 gives you a lot more time before significant progression, that works for me.
Totally agree 👍🏻