So far, the research doesn't show improved outcomes for intermittent ADT with advanced prostate cancer, the way it does with early-stage PCa: last I heard (a few months ago), overall survival actually declines (slightly) with "ADT holidays" for late-stage PCa in the studies they've done so far, but I'm hoping that will change as the research accumulates and they find the best way of doing it. Right now, I'm too nervous that if I stopped ADT, my castrate-sensitive PCa would return as castrate-resistant after a few months (or years), and I don't want to roll that die quite yet.