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What is a Quick Rise in PSA?

Prostate Cancer | Last Active: Sep 1, 2025 | Replies (58)

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Profile picture for heavyphil @heavyphil

TRUS is Trans Rectal - You do NOT want that one! You want an MRI guided transperineal which can access more areas of the gland. Do not settle for the rectal - go elsewhere.
Your PSA rise is concerning after so many years in a certain range. Some aggressive forms of PCa can exhibit lower levels of PSA to begin with so the absolute number is not the issue - it’s the jump.
If you’re going to do this, you need to be certain that an aggressive cancer is not in the picture. You really need an MRI before the next steps can be taken; if anyone tells you that’s not the case, run like hell…
Phil

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Replies to "TRUS is Trans Rectal - You do NOT want that one! You want an MRI guided..."

Hi @heavyphil -
Yeah, I’ve had a TRUS before just to measure my prostate, so I know what that is. However, some information I came across online indicates a TRUS guided biopsy is through the perineal area, with the TRUS guiding the placement. Others just say it is TRUS with needle attached to the TRuS and entry through the rectum. So I am slightly confused on conflicting terminology. That being said, I have also read many things that say the traditional TRUS biopsy (not through the perineum) is the gold standard (with a low risk of complications). So juts curious why you are saying to run if that is the plan? Not questioning - just curious to get further input. (I do plan to get clarification from my doctor). I think I would prefer through perineum, but I haven’t seen anything to indicate that the standard method is bad. (Except for one article I was skimming which I thought sounded pretty negative against biopsies and treatment in general and when it got to metformin and ivermectin as alternative treatments, I promptly stopped reading and closed the page)