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Side effects of prednisone

Polymyalgia Rheumatica (PMR) | Last Active: Jul 2 7:57am | Replies (23)

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Question about side effects of Prednisone. 63 year old male. Diagnosed in April 2025, started on 15 mg around May 4th. Tapered to 12.5 mg after a month with small amount of pain/stiffness, then tapered to 10 mg after 3 weeks, also with minor pain/stiffness. I am on week two of 10 mg and notice a few side effects of Prednisone such as thin skin, a generally weird feeling like I am not in control of my body, fatigue, etc. Yesterday on a hike I found that I had anxiety when driving on a cliffy- type of road. Let me explain: As I was driving to the hike (Colorado--Mountains!) I had a cliff on the driver's side of the car. This typically does not bother me nor does a reasonable exposure to heights when hiking or skiing. In fact I have been a skier and climber for over 50 years. I would not say that I love "exposure" (as it is called) but usually deal with it quite easily. Yesterday however, when driving I had the typical visceral twinge with the exposure along the driver's side of the car. It was not just a twinge but more like an electric shock in my pelvis and legs. It was clearly related to the cliff on my side of the car because the exposure I was experiencing would come and go and the "twinges" would follow perfectly with the "stressor" of the cliff as it came and went from my side. I was wondering if anyone else has had a lower tolerance for heights or stressful events while on prednisone. My hypothesis is that the adrenals are not operating on their own with the right secretion of cortisol, adrenaline, etc. In other words the prednisone alone is not enough to abate the stress symptoms of exposure to heights in this case. Any thoughts or experience or references on this are welcomed.

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Replies to "Question about side effects of Prednisone. 63 year old male. Diagnosed in April 2025, started on..."

I think you're right. I've tapered over the past year from 60 mg prednisone down to 2, to treat GCA and PMR. As I have gotten below 10, I've had occasional days where I felt minor anxiety, fatigue, or depression. I've read it's common to feel some anxiety when tapering prednisone. I don't have any references other than Google. It sounds like your body wanted extra cortisol to deal with the stress of the exposures, but it didn't get it, so it responded with anxiety. It's like pressing your foot on the gas pedal of a car and not getting any response.

What is your taper plan going forward? It sounds like you might need a slower taper if you're feeling some pain and stiffness, plus the anxiety indicating that your adrenals are being nudged to become active again. Also, you really haven't been receiving treatment for very long. I think for most people it takes at least 1 - 2 years for the PMR to burn itself out.