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Alternative to Tamoxifen other than AI
Breast Cancer | Last Active: Sep 5, 2025 | Replies (49)Comment receiving replies
This is all so interesting—and disheartening— as I am just starting on letrozole for ILC. If I wind up with such bad side effects, wouldn’t it be wiser to just do mastectomy and avoid all the possible side effects? I get more disillusioned the more I read and want to believe doctors know best..,and then seeing that taking letrozole could cause so many problems to an aging (78 yo) body. I need some positives on how to proceed. Wish everyone well on our journey!
Replies to "This is all so interesting—and disheartening— as I am just starting on letrozole for ILC. If..."
I have mastectomy but still on AI now 3 years, as it's the estrogen that is produce in your fat now that could cause trouble. Started with Tamoxifen with growth in uterus then Letrozole bone aches and diagnose with arthritis, then Anastrozole similar side effects but great mood and now Exemestane which just started and suppose to have no bone lost but all other symptoms and shitty mood. All the best to you all riding through the same journey!
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Just to add in--I've been on letrozole for almost three years. I'm 71. No side effects and bone density remains fine. You might consider trying it and then stopping if it is too uncomfortable. Many women have no problems--not to discount those who do.