I really like the promise of this small section from the article

“We’ve typically looked for single-gene mutations—BRCA1, BRCA2, MLH1—that signal elevated risk. But most inherited risk isn’t carried by one rogue gene. It emerges from the accumulation of many—a polyphony of small variations, each nudging risk ever so slightly higher. Today, advances in genome sequencing and computational modelling have begun to untangle this architecture. Sophisticated algorithms can scan entire genomes, mapping how thousands of tiny genetic variations interact. One such model, attuned to thousands of genetic loci, can already predict adult height. Nutrition still matters, but the precision of these forecasts represents a remarkable advance.”

My father died of prostate cancer, and my brother has it, but neither has BRCA2. I know a number of people who are brothers and all brothers got PC. This DNA testing may finally give people a clue as to the likelihood of it happening. Maybe they can use crisper technology To modify some of the genes so that it won’t happen. Well, that’s the future, Probably not our future.

It’s interesting that the article specifically avoided prostate cancer. We do have tools that have changed things so that, for example, Gleason six people can usually avoid doing anything. We don’t know if somebody’s cancer is likely to be metastatic, but we now have the decipher and other similar tests to give a chance of knowing the odds. We have the PSE test that can decipher those fragments in the blood and decide, with high percentage accuracy, whether or not there is at least cancer there.

It seems that it is unlikely that a Gleason 4+3 And above will be able to get through a long life without problems. It’s possible, but knowing about an aggressive prostate cancer and treating it does give you the opportunity to do something that will in all likelihood extend your life.