Thank you for explaining this to me. It really helps to hear from someone like you who has a grasp of all this. I am definitely still on the learning curve. My PCP wanted me to take Fosamax. She agreed to give me HRT, but she knew nothing about it, so I had to tell her what I wanted. I have an appointment to visit my gynecologist, but I cannot get in for 2 months. So now I have the prescription: 0.025 mg/day Estradiol twice weekly patch. The Lancet study you posted is the one I read. That study indicated that sequential dosing resulted in less breast cancer, so I have 200 mg of progesterone to take for 12 days. No one has indicated how to take it, but I think I am to take it on the 17th day at the end of the cycle. Do you think the sequential dosing is a mistake for someone just starting this? I was basically prescribing for myself since my PCP was opposed to HRT in favor of Fosamax.