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Profile picture for Sue, Volunteer Mentor @sueinmn

Yes there are a number of blood markers that show inflammation. But, not everyone forms those antibodies, even if they have RA or another autoimmune inflammatory condition. Then they are known to have "seronegative [condition]" - this is more common with some conditions than with others.
And, some people can have a number of inflammatory processes and no blood markers, decisions must be made based on symptoms. Doctors are not sure why this happens.

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Replies to "Yes there are a number of blood markers that show inflammation. But, not everyone forms those..."

I understand sero-negative RA. My late husband had this. His x-rays looked like mice had been eating away at his bones in his toes and hands. He had so much pain. May he rest in piece. All the steroids and Humira finally took their toll on his body.