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Ibuprofen is an NSAID (non-steroidal anti-inflammatory drug) which should not be taken with prednisone because of the high risk of gastric harm. I tried stronger slow release Panadol (Tylenol) occasionally way back, but it only took the edge off the pain and doesn't reduce PMR inflammation or change the over-active immune response of PMR.

Are you taking prednisone, and at what dose?

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Thank you for your response. Because of the bad side effects I have gotten from all of my PMR medication‘s right now I am off everything! I still have dizziness from taking methotrexate!!! I have seen several doctors and hopefully eventually this methotrexate will wash out of my system I’m hoping. Yesterday my rheumatologist was already to give me another PMR medication which honestly I’m afraid to take because nothing has worked for me except made me sicker. As usual I am still taking one day at a time hoping for the best!

Hi I’m not sure if you got my last comment. Right now I am not on any medication‘s for PMR. I am hoping that the methotrexate that I took will wash out of my body as soon as possible because it’s making me dizzy. I visited with my rheumatologist yesterday she was all set to give me another medication for PMR even though I’m still dizzy from the methotrexate which has not washed out of my system yet to take a while. I learned that I am very very sensitive to any medication for PMR it’s not anybody’s fault it’s just the way my body is so I have to take the medication that’s the least toxic for me which at this point maybe Tylenol. Thank you very much for your response!!!