I was put on Anastrazole first, starting about 3 months after finishing chemo/2 weeks after radiation. It took about 5-6 months to get to the point where I was painful all the time - sharp pain that would move around, today the left ankle, then right hip etc. finally at 8 months, he said “you shouldn’t have to live in pain” and took me off. I was classified as pre-diabetic because of an A1c of 5.9. All lipids had been elevated before but had trouble with statins so unsure if Anastrazole contributed to that. About 6 weeks later started exemestane. First 2 months were fine but then I started month 3. Weight gain (no other changes in diet or exercise, just 10 pounds in 1 week - “not a side effect”, mild discomfort in hips and lower back, weakness on standing, extreme fatigue (before the insomnia started), insomnia (currently I get 4-6 hours a night if I’m lucky) and over the last few months, developed a tinnitus in the left ear. While he noted I “looked tired” 4 months ago and we discussed it, the suggestion was that I’m just depressed. He did at next visit test for multiple things that cause fatigue and (good thing) all were normal but that left me with no reason and therefore no treatment. Good things are that I had a mild osteopenia on the Anastrazole and current bone scan was normal (exemestane does have slightly less effect on bone over Anastrazole), A1c now 5.4 and fasting glucose under 100, and only abnormal lipid is mild increase in ldl - all that seems better on the exemestane. Overall, exemestane MAY be better than Anastrazole for me. I may ask about going to the every 2-3 day schedule - still doing research on that. It’s always a tough call because as many others have indicated, this is all “rock vs hard place”. Do the meds with all the inherent side effects but decreased chance of reoccurrences or take the chance off them and hope for the best but maybe better quality of life. Unless this becomes intolerable, I think I’ll stay on because I certainly don’t want to go through all this again if I don’t have to.