I have been on hormone therapy for almost 10 months now, I was diagnosed late last year with Gleason 9, with metastasis to one lymph node and pelvis. My cancer growths have all stopped and greatly diminished from the hormone therapy. However, there are side effects: hot flashes, joint pains, and fatigue. The fatigue is the worst side effect, but if you stay active and lift weights, the effects of the fatigue are not too bad. For example, if you are sitting around, maybe watching television, all the sudden I will get really tired and want to sleep, but if you get up and walk around a bit, the fatigue dissipates very quickly, If you can, it is very important to keep your muscle strong as the lack of testosterone will cause rapid muscle weakness and joint problems, etc. I workout 4 days per week, and so far I have maintained my strength and energy. Hope this helps explain it, while it is just my experience. Everyone reacts different. My thoughts are with you and your husband and hope for your recovery.