Hmmm, I wonder if some people develop a tolerance for prednisone, or maybe a physical dependence on it?

I wish I'd bookmarked it, but there was some research done that showed people who controlled inflammation consistently had more success at reducing and getting off prednisone. Consistent disease control seemed to be the key. It makes sense that repeated flares and the return of inflammation could make it harder to get off prednisone. The one inflammation/pain flare I had last year felt like a huge setback and kicked off a few other nasty things - thrombosis, Morton's Neuroma, trigger finger, upper leg nerve pain etc. So I'm not in a hurry to get off prednisone any more, just happy to reduce slowly and surely while hopefully avoiding the return of inflammation.