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Recurrent Vaginal Cancer

Gynecologic Cancers | Last Active: Aug 9 10:15pm | Replies (22)

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Profile picture for jonut @jonut

I was diagnosed with stage 4 endometrial cancer in Aug 2023. It had spread to my lymph nodes. In oct 2023 I had a complete hysterectomy and removal of several lymph nodes. I went through chemotherapy and radiation in 2024. In Oct 2024 my oncologists found a spot on my vagina that was serous carcinoma, the same cancer I had before. She did a partial vaginectomy and started me on keytruda infusions. In May 2025 she found another spot and 3 weeks performed another partial vaginectomy. I will start taking oral Lenvima daily in addition to the keytruda infusions. I don’t understand why you could not have this done.
Does anyone know what side effects I should expect from the Lenvima and keytruda?

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Replies to "I was diagnosed with stage 4 endometrial cancer in Aug 2023. It had spread to my..."

@jonut Welcome to Mayo Clinic Connect and to our Support Group. You've really been through so much in the past few years. It's good that your cancer care team is monitoring you so carefully. That's a lot of surgery in a short period of time.

This is a very active Support Group and Discussion and so I expect you will get helpful responses to your queries.

How are you feeling?

I will be starting Lenvima 20mg August 5. I read its pretty tough diarrhea naseau muscle n bone pain.
There's a discussion group on fb about keytruda/Lenvima. Look into it very informative.