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Adding a second medicine question
Prostate Cancer | Last Active: Jul 19, 2025 | Replies (37)Comment receiving replies
"Close to 70% of people with PC are cured or at least go into long-term remission." I hope and pray you are correct. With Stage 4a, Gleason 9, and Decipher .99 at diagnosis its been hard for me to be positive. I've had removal + radiation + ADT (Orgovyx 29 months). Although my PSA has been < 0.01 for 25 months now post radiation, It's scary to risk coming off ADT. But, someone else on here said that maybe the "PSA trajectory" has been changed. I know I probably need to come off ADT to see what will happen, but that's scary.
Replies to ""Close to 70% of people with PC are cured or at least go into long-term remission."..."
It is very common to take a drug “holiday”. After maybe 6 months, or If and when PSA rises, vacation is over and we go back to work.
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Yes, your cancer is a high risk cancer. The thing is, you’ve gone 2 years with undetectable PSA. Can’t hurt to stop for one month to see if your PSA starts rising.
In my case, after almost a year of undetectable, I reduced my Zytiga From four pills to three to see if it would help with brain fog. In 18 days, my PSA went from .2 to 1, Back to four pills right away. I have BRCA2 Which causes real problems with prostate cancer growing from time to time. So in my case, I can’t stop the drugs without my PSA rising.
I know a lot of people with Gleason nine that have stopped taking the drugs and been able to do it for quite a long time, Over a year, Before their PSA started to rise in most cases.