I tried Journavx in February 2025. I have a HUMANA MEDICARE ADVANTAGE PLAN. Humana did not cover it, but I requested them to consider putting it on their formulary and they did at Tier 4 which is VERY EXPENSIVE. The drug is not indicated by the FDA for chronic pain, just acute pain. The dose is twice daily after a loading dose. Due to the expense, I only took 1 tablet daily but sometimes I took it twice daily. It appears to have a very weak affect on pain so I no longer take it. The expense is just too much as well.

I have followed this drug the last 3 years hoping it might be an answer to the burning in my feet due to idiopathic small fiber neuropathy. I retired from a major international pharmaceutical company, and have been very involved in research for new neuropathy treatments. Unfortunately, all the current drugs just treat symptoms and do not address the root cause. But, one drug that I have followed for years is called ENGENSIS from Helixmith Pharmaceuticals in South Korea. It actually can reverse nerve damage but the company has not put out an update on the drug for over a year so I don’t know if it’s still viable or not, and they will not answer my email inquiries. The drug Pirenzipine from WinSanTor seems to be dead. I think they just ran out of money. So, in conclusion, other than ENGENSIS, I don’t think there is nothing in research that really makes a difference in the disease.