100% anxiety goes with PC , especially if you have a family history ( like me ) ....but im not sure he SSRI or Zoloft is the answer . If he keeps active , goes hiking , keeps busy the anxiety wont get him so much . Also SSRI have a horrible safety profile with all sorts of suicides and many other things . I would recommend Ativan or Clonazapam to get him over the real bad days instead maybe . Im not a Dr but I do know about anxiety - my father passed away with PC when he was 67 . About 25 years ago . I was his care giver right up to the end . Terrible death from PC .... So when I was diagnosed with it I freaked out ! Now I am a lot better . I hike almost everyday with Dogs in mountains 8-15km per hike . I do swimming and Suana's and a bit of the weight room too ! 5 years ago Operation for 3+4 Gleason , PSA was 4.1 back then prior to surgery . Then EBRT 2 years ago when PSA slowly climbed to 0.14 PSA , Then I got 22 sessions and no ADT . Now PSA stands at about 0.04-0.031 . Very low numbers . The Victoria Cancer Hospital and my Radiation oncologist released me ( discharged me ) and just said to report to my Urologist. Urologist said to get PSA test every 6 months now . I said every 3 months and he was fine with that. Anyway Anxiety goes with PC , for sure ...your 100% right there !