Mike, you have taken on a challenge, having to deal with the "long-term Prednisone use results in long-term metabolic side effects."While researching GLP-1, metformin, Jardiance, and PMR, I asked eight free Chat AIs the same questions and compiled the information into a Google program called NotebookLM. Taking your quote, "long-term Prednisone use results in long-term metabolic side effects." I ask Gemini to create a prompt to ask NotebookLM.
I've attached two PDF files: one with your quote and one with the audio summary in text format, which provides the necessary information.

Summary from the NotebookLM Audio
This audio segment delves into a compelling personal account of Jardiance, a diabetes drug, and its unexpected positive impact on a listener's Polymyalgia Rheumatica (PMR) symptoms. The core of the discussion revolves around an "N of one experiment," highlighting how this individual observation suggests a potential repurposing of Jardiance as a drug, extending its utility beyond its typical indications. The conversation also explores the emerging field of immunometabolism, explaining how drugs like Jardiance, Metformin, and GLP-1 agonists influence the intricate relationship between the immune system and the body's metabolism, potentially offering a steroid-sparing approach to managing inflammatory conditions like PMR while emphasizing the synergistic role of lifestyle changes."

Mike, keep in mind that this is from AI, and AI chats tend to present their best side with a polished, well-worded touch.
I made this audio shareable, so it should work
The audio file is 20 minutes long.
https://notebooklm.google.com/notebook/39be6ca8-52be-46c5-99a3-3a00327077b1/audio