Will let you know what happens if I end up trying it. I have heard some people have less side effects on Yonsa than abiraterone but my doctor doesn’t think it will make a difference so need to see if he is even willing to have me try it.

Thanks,

Phil

I did not do well on Yonsa. I took a half dose of Yonsa and methylprednisone twice daily for a few days but started to get high blood pressure, headache and unsteady, effects were similar to abiraterone but probably not quite as bad.

Am also on Orgovyx. I may start on Nubeqa. I will be on medicines for 18-24 months, am 3 1/2 months on Orgovyx and am in radiation.

I am wondering what happens when I try to get off an ARSI like Nubeqa? Nubeqa is often prescribed indefinitely. Does anyone have experience getting off of the first or second generation ARSIs while still hormone sensitive? Hoping I will still be hormone sensitive at that point and can attempt to finish treatment as doctors are aiming for curative intent. Do the blocked androgen receptors come back ultra sensitive and increase my risk in the long run?

Nubeqa is actually not approved for what I have non metastatic hormone sensitive. I am oligometastaic with localized 2 lymph nodes positive and hormone sensitive. There are no test results yet for my scenario but the doctors are willing to prescribe Nubeqa for me as I am sort of in a grey area in terms of metastatic.

Thank you,

Phil