Ask you doctor if you can do a trial of low dose naltrexone. Naltrexone is thought to minimize inflammation and modulate the immune system. I have about a 50% reduction in pain with a 3.5 mg dose per day. It is a prescription drug and must be created in a compounding pharmacy for this low of a dose. You start with a very low dose like .5 or 1.5 mg and work slowly to 4.5 mg. I dropped back down to 3.5 mg as that dose worked best for me.

It does have some side effects the first week or two. I was tired some days and had more energy on others to begin with. I had insomnia if I took it too late in the day. Now I just get more energy about two hours after I take it and it relieves the pain...nice to wake up and not have my knees throbbing. I also had vivid dreams (not nightmares) for about the first two weeks.