Congratulations for tapering off Prednisone. I hope you can stay off Prednisone.

I was on Prednisone for 12 years to treat PMR until I was able to taper off with help from Actemra. It was a bumpy road for me too including low neutrophil counts. My counts were low but my absolute neutrophil count (ANC) was the more critical value for fighting infections. When my ANC was somewhat low ... the recommendation is to skip one injection rather than discontinue treatment permanently.

My difficulties mostly happened when I was still on Prednisone along with Actemra. When I finally got off Prednisone my labs normalized and I haven't had many problems since then. I think it was "too much immunosuppression" when I still needed some Prednisone before I was able to taper off. I'm on Actemra without Prednisone now and I don't seem to have any problems with any of my lab values that are being monitored.