I had one done back in 2019 for the first time and I noticed the new rheumatologist I've been seeing ordered it as well (the old one probably ran it more often than that the one time, but I probably wasn't paying close attention). I increased from a 21 to a 42 - when I asked the new rheumatologist if that meant my risk had increased based on the labs, she sort of shrugged and said, "Well, I run it, but to be honest I don't think the results always correlate to reality" . . . My understanding is where it's most helpful is in guiding doctors with patients who are seronegative for RA, but are symptomatic. The panels can help them figure out what's going on if their TNF-alpha or interleukin-6 levels are elevated despite negative rheumatoid factor and Anti-CCP labs which are commonly associated with RA. In my case I have high RF with negative Anti-CCP, but I have mostly back and hip inflammation - but I don't have the HLA-B27 protein that is usually linked spondyloathropathy. I'm a mixed bag of labs that don't match symptoms and vice versa, which is why I think both doctors have run the Vectra to see if it can give them any additional useful information into what my immune system is doing. Hope that sort of helps!