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Salvage radiation decision: with or without hormone therapy?
Prostate Cancer | Last Active: Jul 30 6:54am | Replies (58)Comment receiving replies
There is a study published by Dana Farber about the timing of salvage radiation. A simple Google search should find it. It suggests that starting SRT prior a recurrent PSA after RP reaching .25, in certain circumstances, can lead to better results.
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Here is that info
From Ascopubs about what PSA to do salvage radiation.
≤0.2 ng/mL: Starting at this level maximizes disease control and long-term survival. Patients treated at PSA < 0.2 ng/mL achieve higher rates of undetectable post-SRT PSA (56-70%) and improved 5-year progression-free survival (62.7-75%). Delaying SRT beyond PSA ≥0.25 ng/mL increases mortality risk by ~50%.
0.2–0.5 ng/mL: Still effective, particularly for patients with low-risk features (e.g., Gleason ≤7, slow PSA doubling time). The Journal of Clinical Oncology recommends SRT before PSA exceeds 0.25 ng/mL to preserve curative potential.
0.5–1.0 ng/mL: Salvage radiation remains beneficial but may require combining with androgen deprivation therapy (ADT) for higher-risk cases.