Yes, the first time I had the infusion I felt like I had the flu for a week after. The second time it was similar but less time and then after that it was just mostly bone pain. Especially in my back, arms and legs. I was told eventually by a PA at the oncologist office that you can take a 24 hour antihistamine (Zyrtec, Claritin) to help with the symptoms. You take 1, 24 hours before, then again on the day of and for 2 days after. It has helped me have less bone pain from the infusions.