Hi there - I'm in my ninth month of taking Verzenio at 150mg. My liver enzymes shot up after the first few weeks so I took a break of a couple of weeks. Since then my blood labs have been fine. I'm more tired than I used to be (not the true fatigue that I had during radiation, but I definitely like my bedtime). I'm not sure if that's the Verzenio or the Anastrozole I'm taking. The "shitty" side effect (pun intended) is the diarrhea. The diarrhea itself is managable with loperamide (Imodium) when it comes on. But it's the urgency that has been a challenge. I don't really notice it too much when I work from home three days per week because when you've gotta go, you just go. In the office is a little more noticeable, but it's still quick, easy access to a bathroom. But I've had more than one experience of having to leave both in in-person or Zoom work meeting because I suddenly had to use the bathroom. But the worst is being out and about. I'm always on the lookout to know where the next bathroom is, just in case. I 've had a couple of times when driving somewhere and I've come sooooo super close to losing it right there in the car. Like REALLY close. Having said this, I usually don't have diarrhea two days in a row (I probably average 3 days per week). So on the 2nd day (after taking Imodium the day prior) I'm usually okay and don't worry about it. If it gets to be the 3rd or 4th day, I know to be cautious and maybe even take Imodium pre-emptively. BUT - with all this Imodium-taking, it's super duper important to pay attention to constipation, as well. I had one particularly terrible bout of constipation that almost sent me to the dr. so I've got sort of a routine with balancing my diarrhea, Imodium, and Miralax. I'm been trying to gut it out at 150mg - but with all if this diarrhea, my oncologist and I are experimenting and I'm going to try one-day per week of skipping a dose and see how that impacts the subsequent days. But overall, I'd say it hasn't been super terrible. It certainly stinks, but it hasn't been the worst thing to deal with (although I might have it a little easier than most as I work from home 3 days per week and have a very understanding boss and co-workers - which really helps). I just keep counting the months until I'm done. It doesn't rule my life, but certainly impacts it. But overall, I actually feel better since my diagnosis - quit drinking, started eating better and exercising. The diarrhea impacts my life but doesn't ruin my life. And since I know it's only for the next 15 months, I figure I can deal with it. My advice: just plan ahead when increasing the dose. Keep Imodium in your purse. Tell your friend or spouse that when they are driving and you say you need to pull over to use the bathroom, it means NOW. Keep reading bulletin boards to hear how others are dealing with the diarrhea and see if any of their tricks (taking the dose at a particular time of day; taking Imodium preventively; eating certain foods) works for you (I haven't found my magic bullet yet, but if I do - I will certainly post about it). Hang in there. You can do it!