ADT, Brachytherapy, IMRT...done!

Posted by callibaetis @callibaetis, Feb 10 5:26pm

Just thought I'd share. Started this journey in spring 2024. Gleason 4+3. Decipher 0.78. PSMA scan negative outside of the prostate lesion. PSA 13.4 when I started Orgovyx in early August. Testosterone 582. LDR brachytherapy in early October followed by twenty-five sessions of IMRT (completed in early December). Finished six months of Orgovyx last Thursday.

So, blood panel today. Testosterone up to 5 (wow, it more than doubled, last November, and I presume last Thursday, it was less than 2.5 😁). PSA 0.06. The rest of the blood panel was good, lymphocytes excepted (which is normal post radiation). Will recheck in one month, then every three months thereafter for two years.

Now it's a matter of watching, waiting, hoping and living.

And I forgot....shoveling snow.

All the best to all!

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@callibaetis

I was on ADT for a six month period that preceded, ran concurrently with and followed radiation. PSA remains detectable following radiation owing to the fact that one still has a prostate.

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oh right! missed that.

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@capatov

Gleeson 7 with 7.1 PSA led to same treatment plan as you. Six months Orgovyx followed by 23 IMRT treatments and one high dose brachytherapy procedure at major university health center. No issues from ADT except occasional fatigue but short lived. Waiting to go back for first post treatment blood work and PSA.

I would strongly recommend this treatment protocol to anyone vs. surgery.

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I agree. After researching the options this course of treatment struck me as providing the best potential for providing a favorable outcome. I initially was set to do HDR brachytherapy but an anatomical complication precluded the procedure. LDR brachytherapy was still a viable option, so I went back a couple of weeks later.

Good luck with your labs!

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@tjv1156

oh right! missed that.

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No problem. Good luck with the rest of your treatment journey!

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@tjv1156

So no adt for now? I can’t wait to get off it but i still have 3 months to go. Plus at least a couple months after I stop . 7 more radiations. I’m keeping fingers crossed it knocks my PSA to ‘undetectable’

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Anyone on Orgovyx that developed anemia?
My Folate RBC is low.

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My stats are similar and I'm researching treatment options. Where did you get brachytherapy and your other treatments. So far I've seen 2 urologists and a radiologist and none have even mentioned it.

How are your side effects so far? RP scares me to death.

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@tk192

My stats are similar and I'm researching treatment options. Where did you get brachytherapy and your other treatments. So far I've seen 2 urologists and a radiologist and none have even mentioned it.

How are your side effects so far? RP scares me to death.

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My urologist dismissed brachytherapy as treatment option. From a radiology standpoint, it’s more lucrative to dial up a radiation treatment plan (as opposed to a brachytherapy procedure). Too, brachytherapy is a specialized procedure offered by relatively fewer practitioners. When combined with ADT and supplemented with some form of EBRT it appears to be a viable and effective treatment for more aggressive localized prostate cancers. At least that’s what I was and am still hoping for.

My brachytherapy was performed at Huntsman in Salt Lake City. The IMRT and ADT were locally provided in Montana.

Whatever side effects that I’d experienced were pretty much done a month or two after completing treatment.

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@taeguab

Anyone on Orgovyx that developed anemia?
My Folate RBC is low.

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Yes, but much like anemia of chronic disease there is no therapy as far as I know.

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