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Prolia then Evenity?

Osteoporosis & Bone Health | Last Active: Jun 30 10:08am | Replies (12)

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Thank you, Michael.
I think my doctor chose Prolia so that I can take it for the duration of my required aromatase inhibitor medication (3-1/2 more years). I think it’s recommended more frequently than Evenity, Tymlos etc. for post breast cancer patients who might be at risk for developing bone cancer. Once I’m done with it, she feels Evenity will help build up my crumbling spine. Does that make more sense to you?

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Replies to "Thank you, Michael. I think my doctor chose Prolia so that I can take it for..."

After a quick ChatGPT session, it does not look like Evenity is contraindicated for aromatase inhibitors, but it also looks like Prolia is the go-to medication for it's safety profile. During the 2025 World Congress on Osteoporosis, Dr. Leder mentioned that if he was to transition a patient from Prolia to an osteoanabolic, that he would first use a bisphosphonate to get better results with the osteoanabolic. That said, depending on your situation, age, T-scores, he might consider keeping you on Prolia and just add Forteo for a few years as a booster. I talk about that in the Prolia presentation https://youtu.be/hnj1tFUAK3M?si=JspNYP-FhtMiiQUA&t=2820

Hi @risagee - After thinking about it last night, I think your doctor might be on the right track. If Prolia is the best treatment while on aromatase inhibitors for 3 1/2 years, using Evenity for one year to counteract the rebound, and maybe build a bit in the spine as well, then taking a second year of Evenity might be outstanding. I have seen a two year study for Evenity and there was still a substantial benefit. This might be the best course to take.

Good luck!