1. < Prostate Cancer

ADT vs. Estradiol

Posted by chuckbies @chuckbies, Jun 9 7:39am

I had a prostatectomy 4 years ago and my PSA is slowly climbing again. The PSMA/PET scan did not show any areas of cancer growth, but I have a family history of aggressive prostate cancer with low PSA. I saw an article on the Mayo website about an Estradiol patch instead of ADT. Does anyone have experience with Estradiol? How does it compare to ADT?

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chuckbies | @chuckbies | Jun 17 8:22pm

Very helpful everyone - thank you!

Quick question: do I need a referral to get an appointment with Dr. Kwon or his team at Mayo? I followed Mayo's online process for requesting an appointment. I went through the first round of questions over the phone, and I said I would like to setup an appointment with Dr. Kwon. The individual I was talking with was with Mayo Radiation Oncology (someone in their intake dept). They said I'd be getting a call back from scheduling. It's been about a week and I have not got a call back from scheduling. What is a reasonable amount of time to expect a call back or do I need a referral?

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1 reply
lag | @lag | Jun 18 7:17am
In reply to @chuckbies "Very helpful everyone - thank you! Quick question: do I need a referral to get an..." + (show)
@chuckbies

Very helpful everyone - thank you!

Quick question: do I need a referral to get an appointment with Dr. Kwon or his team at Mayo? I followed Mayo's online process for requesting an appointment. I went through the first round of questions over the phone, and I said I would like to setup an appointment with Dr. Kwon. The individual I was talking with was with Mayo Radiation Oncology (someone in their intake dept). They said I'd be getting a call back from scheduling. It's been about a week and I have not got a call back from scheduling. What is a reasonable amount of time to expect a call back or do I need a referral?

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Dr. Kwon is in Urology, not Radiation Oncology. Though they work closely together, you would be better off calling Urology Scheduling directly. There is a specific number for Kwon appointments: 507-266-5060, and they answer it from 7 am to 6 pm Central time, Monday through Friday.

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chuckbies | @chuckbies | Jun 18 11:57am

Thanks for your response. I talked to Mayo Clinic Urology but they said they won't see me if my PSA is less than 0.4, and it currently is at 0.2. I'm currently working with an Oncologist at another Cancer Center. I was thinking it would be helpful to go to Mayo and get a Choline 11 scan and a second opinion from a Mayo Oncologist. Does anyone know if Mayo Oncology uses Choline 11 scans?

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pjsatz | @pjsatz | Jun 18 5:06pm
In reply to @jeffmarc "There’s actually two possible uses for estrogen. One is to replace ADT the other as an..." + (show)
@jeffmarc

There’s actually two possible uses for estrogen. One is to replace ADT the other as an adjunct to ADT.

Adding estrogen in a small dose increases the sex drive, which is almost eliminated by ADT. Usually, your body has some estrogen, but it’s normally hard to find if you’re on ADT. This exact issue was discussed in a recent prostate cancer bi monthly meeting where a GU oncologist answers questions for the first hour and discussed the use of some estrogen for that purpose.

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Did anyone mention what dose level of Estradiol are working as an adjunct to ADT to bring estrogen back to a normal level for males? It sounds like it’s not widely used or tested but wondering what may be working.

Thanks,

Phil

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1 reply
lag | @lag | Jun 18 5:52pm
In reply to @chuckbies "Thanks for your response. I talked to Mayo Clinic Urology but they said they won't see..." + (show)
@chuckbies

Thanks for your response. I talked to Mayo Clinic Urology but they said they won't see me if my PSA is less than 0.4, and it currently is at 0.2. I'm currently working with an Oncologist at another Cancer Center. I was thinking it would be helpful to go to Mayo and get a Choline 11 scan and a second opinion from a Mayo Oncologist. Does anyone know if Mayo Oncology uses Choline 11 scans?

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Mayo Rochester has offered these scans for years. My husband has had many Choline 11 PET scans, ordered by Dr. Kwon, starting in 2011 and continuing to the present time. I am sure this scan can be ordered by any appropriate provider at Mayo. I believe that Mayo is also one of the few places that produces its own Choline 11 for clinical use.

It is frustrating that your PSA is too low for you to be seen soon, but keeping in mind that having a too-low PSA also has many advantages. 🙂

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jeff Marchi | @jeffmarc | Jun 18 5:59pm
In reply to @pjsatz "Did anyone mention what dose level of Estradiol are working as an adjunct to ADT to..." + (show)
@pjsatz

Did anyone mention what dose level of Estradiol are working as an adjunct to ADT to bring estrogen back to a normal level for males? It sounds like it’s not widely used or tested but wondering what may be working.

Thanks,

Phil

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I heard a single patch, from the oncologist who answers questions at the BImonthly CSC meetings. To replace ADT you need three patches. I am not a doctor and cannot prescribe drugs for you. Ask your doctor about it, but at least you have an idea.

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1 reply
pjsatz | @pjsatz | Jun 19 12:57am
In reply to @jeffmarc "I heard a single patch, from the oncologist who answers questions at the BImonthly CSC meetings...." + (show)
@jeffmarc

I heard a single patch, from the oncologist who answers questions at the BImonthly CSC meetings. To replace ADT you need three patches. I am not a doctor and cannot prescribe drugs for you. Ask your doctor about it, but at least you have an idea.

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I understand, thanks. Have asked a couple of doctors about this and they say it’s an idea they’ve heard but not something they do. Another doctor said he may look into it.

Thanks,

Phil

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