I have been off Repatha for about eight and a half months and am still having lasting side effects from the drug. I had severe edema, tendons snapping for no reason, constant UTI's, back pain, severe edema and severe joint stiffness to the point of falling over and not being able to get back up. Before getting on this drug, I could do Yoga very easily and was very active. I had absolutely no physical disabilities of any kind. I was on it for four years, and the last two years were horrible. I thought that I was aging fast. I was not. It was the Repatha all along. The edema and joint stiffness are the two remaining conditions. My rheumatologist told me that it may take some time to get the damage reversed. My primary sent me to her because I still have loss of use of my dominant hand and I tested positive for Rheumatoid Arthritis. I changed my diet to a strict Mediterranean diet and removed all nightshade veggies. I did this for a month and then the Rheumatologist retested me. I now read negative for Rheumatoid Arthritis. She said that Repatha did such damage to my body, that it is taking time for my body to heal. She feels that it will eventually recede. She told me that she sees many patients that have had long term side effects from Repatha and other injectable cholesterol drugs. In the meantime, I am have a cardiologist appointment coming up. The next concern is that the edema was so severe in my abdominal area there is some concern that it may have done damage to my heart.