My CA 125 was steady at 10 since completing chemo in March of 2024. Prior to surgery it was 460. So Signatura being positive at 10 was very interesting. None the less scans were ordered and there it was in one lymph node. Again I feel it should be routinely done from the start just after surgery and again after finishing chemo and then every three months. It appears it may be far better than CA 125 in detecting recurrence. Medicare covers it so why not? Only problem is that it is either positive or negative. There are no numbers to guide you on some kind of scale.