Looking for people who have high levels of B6 trigger neuropathy.

Well my eyes have been opened to this. I took Twinlabs Stress B complex daily for well over 15 years. It has 40 mg of pyridoxine HCL. I am homozygous for A1298C mutation on gene MTHFR. This has resulted in b vitamin methylation issues. My B6 level was 248 nmol! I have been dealing with distal neuropathy for 8 years, in legs. My story is very complicated, but lets just say this was very much likely the main reason for my overall decline the last 5 years. BE CAREFUL WITH B6 supplements!!
There are cases reported in some taking 25 mg/day chronically. It builds up, especially if you have any methylation issues. The daily rec'd allowance is VERY high in the US compared to other (albeit, smarter) countries. They are ahead of the game.

My B6 test say normal range is 20.0 - 125.0 nmol/L. Mine has been in the upper 100's the past couple of times. I was told this could be why I feel neuropathy in my feet and lower legs. I stopped taking all single type supplements and just take 2 Centrum for men over 50 years old vitamins daily.

Hello, hello!

Both of my neurologists (what? you've got two neurologists? ain't I the lucky guy 🙂 ) advise me to make a distiction between B6 pyridoxine hydrochloride and B6 pyridoxal phosphate. Everything I've read so far that warns about a link between B6 and neurological symptoms has been talking about the former, B6 pyridoxine hydrochloride.

My neurologist tag-team also warns about overdosing on B6 pyridoxine hydrochloride.

Here's wishing everyone a good day!
Ray (@ray666)

Thank you for this information. I have 2 neurologists and 1 neurosurgeon! AND NO ONE ASKED ABOUT ANY EXPSOURES. Not one asked about any B6 I was taking, they all assumed back issues were causing my leg symptoms, and so did I up until 2 weeks ago!

Good morning, bigmuscle72. You've reminded me, I, too, have 2 neurologists and a neurosurgeon. That's not because I'm well-heeled. Far from it. It's only because each doctor I saw, in the end totally stumped, sent me to see another doctor. For a while, I was in the Doctor Collection business. That's why today I can boast 2 neurologists AND a neurosurgeon. If the Doctor Collection business taught me anything, it taught me "idiopathic" meanings idiopathic. The sooner I was able to relax with that reality, the sooner I was able to return to getting on with my life (such as it had become). (By the way, that neurosurgeon –– when I was finally sent to see him –– told me it was highly unlikely that any borderline spinal malformation was causing my balance difficulties, and that surgery would be unwise and likely, a huge disappointment.) ––Ray (@ray666)

Hello @bigmuscle72,

I combined your discussion with an existing discussion titled:

"Looking for people who have high levels of B6 trigger neuropathy"
-https://connect.mayoclinic.org/discussion/looking-for-people-who-have-high-levels-of-b6-trigger-neuropathy/

I did this so even more members would be able to see your post and share their experiences with you and so that you could read about some of their experiences as well.

My B-6 was 59.5

Not exactly B6 Toxic neuropathy. I had blood work done, and it showed extremely high levels of B6. I was happy because I assumed that was the cause and easy to change. But the doctor didn't tell me - or I didn't hear - that I was to fast the evening before. (I take various natural supplements.) I did, and had new blood work. The B6 was in the normal range.

That has also been my experience.Unfortunately , even with a redo, my level was around 72. By that time, neuropathy already settled in. I’ve been disappointed in knowledge around B6, denying certain conditions could create a build up( dehydration, little exercise)
I’ve switched to supplement with no B 6 and now have normal levels.