I had a recurrence on my chest wall 2 weeks after a mastectomy. I then had chemotherapy and 2 suroto get the tumor out with clear margins. I am on letrozole (7-10 yrs) and just finished 2 yrs of Verzenio. My doctor said without those drugs the chance of stage 4 cancer was 70%. Letrozole reduces the risk to 35% and Verzenio takes off another 7%. The risk of stage 4 is lowered a lot. And verzenio keeps working to reduce the division of cancer cells after you stop taking it. Vwrzenio is the biggest breakthrough is BC in 20 years. Although it’s expensive $144,000 for 2 yrs. .