I have had lupus for over 25 years. It is mostly of the skin variety, and that means no sun, but it also affects my gut and makes me tired (and more). The tiredness has gone away with a Methylfolate supplement. It is crazy that it helps so much, but there is information out there that it can help.

Just getting rid of the fatigue would be great, no?

Note that the brand I take is Biotics Research Methylfolate Plus. I cut the pill into eighths (I have a great pill cutter) and it is not a mega dose. Check with your doctor to see if you can take it. I also take a B12 supplement as my gut doesn't like meat or fish anymore (and most other foods, but I have figured that one out) and I think it helps the Methylfolate work. Like Warner68 says, if you can figure out some accomodations for your condition, things can improve. Just Google the heck out of the topic and see what makes sense to try. Good luck!