Darolutamide Monotherapy

There are a lot of people that are on Darolutamide monotherapy who attend the weekly Ancan.org Advanced prostate cancer meetings. Most of them are mCRPC however. I did it for the last eight months and even though my testosterone rose, my PSA stayed undetectable. This is working quite well for those people.

The real study of a lutamide being tested for preventing someone from becoming mCRPC or At least make it take a lot longer to happen is with apalutamide. I know somebody who is actually in the study. The thing is, it usually takes a while before you become mCRPC if on ADT. Took me 2.5 years on ADT before I became resistant. Some people get there quicker some later, so a study is gonna take a while.

You might want to fact check what you said. It was darolutamide that was approved for monotherapy (on June 5th). The point I was trying to make is that Nubeqa alone (as well as other androgen blockers) might provide advantages over prolonged ADT because it allows for increased T. And therefore less genetic pressure on mutation to castration resistance.

I think the problem here is that Darolutamide is not capable of overcoming all testosterone levels. It can for a while, but my oncologist specifically told me that once the testosterone got over around 250 Darolutamide had issues with keeping the PSA down.

Testing will show what’s real.

Following. I stopped my Lupron 3 months ago and doing the Nubeqa mono therapy now. Am at Mayo getting scans now.

A friend has been on Darolutamide monotherapy since last August, treated by Dr. Kwon at Mayo. As of last week, his testosterone was 1100 and PSA undetectable, while the lymph node recurrence has gone dormant.

The Embark study where Enzalutamide and Lupron together worked better than Enzalutamide alone was the basis for not wanting me to stop ADT and keep my T low.

Interesting subject you bring up, however, and I will actually pursue it when I speak to my GU oncologist in another month or so. You are pretty new here, if you stick around I will mention it when I get more info.

Not so new. Diagnosed Stage 4b in October 2022. Started Lupron then did chemo and Nubeqa. Then IMRT. Stopped Lupron after 13 months and have continued Nubeqa for 17 more months. Have had PET scans every three months. PSA has been negligible since chemo.
T has gradually risen since stopped Lupron, current symptoms fatigue and leg weakness.

What was your PSA when diagnosed as Stage 4b?

My dad was this past August but with a PSA of 0.5 and 2 small bone mets, they elected for SBRT alongside Eligard and Nubeqa. I keep dwelling on the decision and whether they should've started chemo alongside the Nubeqa.

PSA was 25 before treatment. Gleason 9. Metasis in lymph node near heart led to chemo.