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Prostate Cancer | Last Active: 9 hours ago | Replies (8)
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Here’s a more technical answer. From Healthunlocked and Mayo Clinic
The duration of castration sensitivity varies widely. Some patients remain castrate sensitive for several years—sometimes 5 years or more—especially if they have less aggressive disease or respond well to treatment. In clinical studies and real-world experience, it is common for patients to remain castrate sensitive for 2–3 years, but many have exceeded this, with some reporting castrate sensitivity for up to 9 years or more
Replies to "Here’s a more technical answer. From Healthunlocked and Mayo Clinic The duration of castration sensitivity varies..."
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And to add to that, recent changes in preferred treatment for castrate-sensitive oligometastatic PCa, such as treating both the prostate and metastases with high "curative" doses of radiation — and adding an ARSI (like a -lutamide) at the beginning instead of waiting for castrate-resistance — have extended the period of castrate-sensitivity considerably for many patients (often for many years). The old numbers were based largely on treating advanced-cancer patients with ADT alone.