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Has anyone had Signatera testing (genetics-based cancer test)?
Gynecologic Cancers | Last Active: Oct 1 6:06pm | Replies (41)Comment receiving replies
Good to know. What was the lowest (or highest) your CA-125 ever measured? Was 10 higher (or lower) than it had been previously?
I've only had CA-125 tests when I also had visible tumors, so I don't know what it would be if I were NED. I suspect in the 5-7 range. But when mine went from 14 to 16, that was definitely a sign that the drug I was on wasn't working, even though the "normal range" goes up to 35. For me, very small changes in CA-125 are very meaningful. The highest mine has ever been is 77 (and that was with a lot of cancer), so my cancer doesn't produce as much CA-125 as many ovarian cancers do.
Replies to "Good to know. What was the lowest (or highest) your CA-125 ever measured? Was 10 higher..."
My CA 125 was steady at 10 since completing chemo in March of 2024. Prior to surgery it was 460. So Signatura being positive at 10 was very interesting. None the less scans were ordered and there it was in one lymph node. Again I feel it should be routinely done from the start just after surgery and again after finishing chemo and then every three months. It appears it may be far better than CA 125 in detecting recurrence. Medicare covers it so why not? Only problem is that it is either positive or negative. There are no numbers to guide you on some kind of scale.
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Both of your responses are very helpful and I thank you. My CA-125 was 268 at the highest with extensive cancer, then went down dramatically after surgery and again with each chemo treatment. This last time it went to 18 from 14 three months earlier and I was concerned but the oncologist wasn't. Now I'm thinking I want to have the Signaterra testing in case the CA-125 isn't reflecting signs of a recurrance. Does insurance cover the testing for ovarian cancer? And what is NED?