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← Return to Signaterra testing
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I am a year post chemo for stage 3 ovarian cancer and requested the Signatura test to monitor for recurrence. My test came back positive but my CA 125 was only 10. My oncologist/surgeon immediately ordered scans even though I was not due for the screening for a couple months. CT showed enlarged lymph node so Pet scan was ordered and the node showed possible recurrence so I had robotic surgery to have node removed with in two weeks of scans. Now waiting for pathology report to determine what next. I definitely will be requesting follow up Signatura testing to see if it is still positive since the node removal. Had I not gotten the testing I would not have gotten the early scans. Lessons learned. Needless to say I am a huge advocate of the testing.
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Good to know. What was the lowest (or highest) your CA-125 ever measured? Was 10 higher (or lower) than it had been previously?
I've only had CA-125 tests when I also had visible tumors, so I don't know what it would be if I were NED. I suspect in the 5-7 range. But when mine went from 14 to 16, that was definitely a sign that the drug I was on wasn't working, even though the "normal range" goes up to 35. For me, very small changes in CA-125 are very meaningful. The highest mine has ever been is 77 (and that was with a lot of cancer), so my cancer doesn't produce as much CA-125 as many ovarian cancers do.