There’s actually two possible uses for estrogen. One is to replace ADT the other as an adjunct to ADT.

Adding estrogen in a small dose increases the sex drive, which is almost eliminated by ADT. Usually, your body has some estrogen, but it’s normally hard to find if you’re on ADT. This exact issue was discussed in a recent prostate cancer bi monthly meeting where a GU oncologist answers questions for the first hour and discussed the use of some estrogen for that purpose.