"Therapy is based on empiric experiences because few randomized clinical trials are available to guide treatment decisions."
https://emedicine.medscape.com/article/330815-treatment
-------------------------
My rheumatologist initially told me to "find a stable dose of prednisone that worked to control my PMR symptoms." My 40 mg starting dose was symptom based and not weight based. I was also 6 feet 3 inches and weighed about 250 lbs.

I gained more than 50 pounds while I was on prednisone. My dose was never increased because of my weight gain. Sometimes my rheumatolgist used my inflammation markers (CRP and ESR) to justify an increase in my dose but mostly it was symptom based.

I was treated with Prednisone for 12 years before Actemra was tried. PMR was refractory and I was still on 10 mg of prednisone. I was able to taper my Prednisone dose more rapidly after Actemra was started. Symptoms of adrenal insufficiency and a low cortisol level required me to stay on 3 mg of prednisone for 6 months before I was finally able to discontinue prednisone

I have been on Actemra for 6 years and off Prednisone for almost 5 years. Actemra works well for me.

Good luck with Kevzara!