All of the ADT Products affect people in pretty much the same way. I’ve been on Lupron for 7 years and then Orgovyx (relusgolix) for about a year. There is no difference in the side effects.

These are the most common side effects

Hot flashes
Fatigue
Muscle deterioration
Bone weakening
Brain fog
Depression
Weight gain
Difficulty in breathing

One big reason I switched to Orgovyx Was cost. Orgovyx Cost me nothing because in January I exceeded the $2000 maximum for Medicare prescriptions so everything‘s free after that. Kaiser started charging me $600 to get my Lupron injection every six months. The pills are a lot better deal at free.

Orgovyx is the one most of us prefer, While the side effects are the same when you stop taking it, your testosterone comes back faster so you feel better quicker. While that list of side effects seems daunting not all of the side effects Hit everyone.. I’ve been on ADT for eight years and it’s really not a problem, Even after 15 years of PC, and 4 reoccurrences my life is the same as just about everyone else, No one knows I have prostate cancer unless I tell them. I just have to get blood test every month.

If you get him on Orgovyx He will not need that 14 days of pills before starting. The thing is, Many doctors do not give those 14 days of pills before, yet it is essential. That tells me the doctor you were going to knows what they are doing and is quite knowledgeable.

Was a PSMA pet scan done on him? This is sort of essential and should be done before starting ADT. You need to ask the doctor about this and requested to be done, Though I would suspect your doctor already knows that.

Have they talked about the fact that he’s going to need radiation and or chemotherapy? Radiation is probably needed, but chemo would only be needed if he had a lot of metastasis. This is something your doctor needs to talk to you about and you need to be real aware of what options you have.

If you would have asked if ADT is the best and safest the answer is NO. The patch trial Completed in England recently and showed that estradiol worked just the same as ADT, but had many fewer side effects. It’s easier on your cardiovascular system, On your bones (osteoporosis), causes fewer hot flashes and less brain fog. If your doctor has not heard of the patch trial, there is a lot of information about it so come back and we can help you. Estradiol is the most commonly used in a patch, But they also have injections and gels that make it easier to use. If you come back and ask, you can get more help on this.

I also had surgery, 3 1/2 years later, it came back and I had radiation, 2 1/2 years later, it came back and I started on ADT drugs, they failed and I started on Zytiga. I switched to Darolutamide Because Zytiga was causing me afib Events and I ended up in the hospital for four days with one. My oncologist said no more Zytiga, sto I switched to Darolutamide Since it has the least side effects of all of the ARSI drugs. I also had SBRT radiation on my spine, where I had a metastasis. Your husband may need the same sort of thing, to metastasis on his body. ADT (or estradiol) can shrink it before radiation.