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← Return to Fun with ADT and testosterone
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Hmmm, the old adage that T is throwing gas on the fire, is it?
I've come off ADT twice, first after triplet therapy, 2nd after doublet. T recovered quickly in both cases in the first three to six months. Why, who knows! A possibility is I exercise quite a bit and I have seen literature about the role of exercise in T recovery.
But, the question my medical team is if my T recovered to 400+ why did PCa not rest it's ugly head until 4+ years the first time, we are at 14 months the 2nd time, no activity. Their answer, we don't know but enjoy!
So, I am not sure about that adage that T is fuel for the fire for all when coming off treatment.
I know I feel better, my activity level doesn't necessarily change on versus off treatment, just how I feel doing things.
If T is 155 now, I guess the question is, would TRT make a difference? I mean if any T is "bad" then you may already be at risk for further recurrence.
This is where the science and art in medicine come in play, the science says T is "bad," the art says in specific cases, is it?
Kevin
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Not quite sure what you are saying. You say your T recovered to 400+, But then you say “ If T is 155 now”. I guess that just a hypothetical?? If your T is stuck at 155 and considering TRT! Some people do it without a problem, Some people have their PSA rise. I think I saw somebody posted that in here a month or so ago. You might go to the top level of Mayo prostate cancer and search for testosterone and find more comments.
Prostate cancer feeds on testosterone even after you become castrate resistant because not all of the cancer is castrate resistant, so ADT works on some of it. This is one of the things I face.
It took 3 1/2 years after my surgery before prostate cancer came back again. Sound familiar? 2 1/2 years later, it came back again and I had salvage radiation.
Neither of us are unusual, PC comes back a lot after surgery. In my case, I have BRCA2 so it’s difficult for my cells to prevent prostate cancer from propagating. In your case, you had an advanced case that required triplet therapy (chemotherapy). That means that the cancer is in your bloodstream and can go anywhere, and come back anywhere. You may end up having to be on these drugs for a lifetime in order to manage the cancer. We are both waiting for the drug that solves this completely.
The graph that you posted at the bottom is cut off on the right side in December of 2024. You don’t clearly say when you stopped ADT