As with any pharmaceuticals we take, individual responses can vary. (If you’ve read the possible contraindications for aspirin, you’d never take one!) ADTs are very toxic pharmaceuticals.

In addition, there are many types of ADT - Lupron, Eligard, Prostap, Camcevi, Lucrin, Zoladex, Trelstar, Pamorelin, Decapeptyl, Firmagon, and Orgovyx. Each was made to improve over an earlier one, but each can have side-effects, which can vary more-or-less from man-to-man.

There is no such thing as zero risk. Even laying in bed and doing nothing carries risks; stepping outside has risks; eating, jogging, driving, yada, yada, yada,……nothing is zero risk.

As for minimizing ADT side-effects, it’s well documented that resistance-training exercise helps to minimize ADT side-effects in men. They first found this with menopausal women - resistance-training exercise minimizes hormonal imbalance side-effects in women. Men on ADT experience what’s called “male menopause” with similar side-effects as women going through menopause.

My medical oncologist warned me ahead of my first Eligard injection to begin resistance training exercise. Me being a gym rat, ramping up my exercise routine was no problem. As you indicated, my experience with ADT was a “breeze….walk in a park.”

This is a clinical trial that was done regarding exercise:
https://journals.lww.com/acsm-msse/fulltext/2023/04000/resistance_exercise_training_increases_muscle_mass.2.aspx
And a 2020 PCRI conference discussion about exercise: https://youtu.be/YE61HSAsFb0?si=sFdWbiZcfHrqfRY-

Yes, there are a number of drugs to counter the side-effects of hormone therapy, but then there are possible side-effects of those as well. (Pick your poison??)