← Return to The Gray Area of Favorable Intermediate Risk 3+4=7

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@llhuscg

Thx for the comments as I too am a Gleason 7 (3+4), 10%, 1 lesion in 12 per the biopsy; no crib, with PNI, PSA is 9.29. It's a challenge to make a decision. Some would say clearly do AS; some would say get rid of the cancer by surgery or radiation. However, I am inclined (as of today) to move towards focal treatment, a very hopeful middle option which unfortunately was not even mentioned in the string of comments. The FDA has approved several treatments and some are covered by Medicare/Insurance plans. I like this option for me because it addresses the cancer which as one comment pointed out can still continue to grow and make subsequent treatment more complicated. Plus the side effects are significantly less than surgery or radiation. I wish there was a decision tree for focal treatment selection, but I haven't been able to find one. Also, it is really unfortunate that the medical bureaucracy is so slow to realize and accept these newer treatments. Thx for the comments!

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Replies to "Thx for the comments as I too am a Gleason 7 (3+4), 10%, 1 lesion in..."

Excellent point about focal therapies as 3+4=7 with certain types of lesions tend to make the best candidates. My surgeon does cryotherapy and we discussed it as an option. And it's covered by insurance. He told me that the effectiveness is less than surgery or radiation and it doesn't remove future potential lesions. But options for additional treatment remain.

Did you choose a focal therapy? Which?

Your statistics are very much like mine were. I chose focal therapy with the objective of trying to balance efficacy of treatment with quality of life/side effects. While there isn't a decision tree to help choose the modality of treatment, one of the key parameter/requirements should be accuracy/precision of treatment. I would rule out anything that isn't in-bore, MRI directed, in real time. I chose TULSA-PRO for those reasons, although I am of the understanding that cryotherapy is also possible under MRI real time direction. Beyond that it is critically important that the procedure be performed at a center of excellence, best done in a hospital setting, and by a doctor who is highly experience in targeting. You want precision (good margins), you want something other than a store front (center of excellence) and you want someone who really knows what they're doing and has significant experience in having done it. That's what maximizes your odds for a favorable outcome in my opinion.