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← Return to Fun with ADT and testosterone
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Prostate Cancer | Last Active: 4 days ago | Replies (15)
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If one has surgery, PSA should stay close to undetectable. If someone has radiation then a PSA of .476 is fine, after so many years on AS waiting for further treatment being needed, you are doing great.
I am 77, time on testosterone and age seem to not be the only reason testosterone comes back. Maybe Orgovyx ends that “rule”
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Yes, I was on active surveillance for about 9 years, before choosing radiation treatment. During treatment, my PSA was close to undetectable while on ADT in 2021; over those months my PSA was 0.008, < 0.008, and 0.008. Now, four years after treatment (I’ll be 70y in a week), my PSA remains stable - I just had my 4-month PSA test this morning; it was 0.473 ng/mL. So, we’re now moving to every 6-month PSA tests.
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As for testosterone (T) recovery after ADT —> Since you were on Lupron for 7 years (and at 77y), it will likely take more time for T levels to recover - longer than just the 8 months you’ve been on Orgovyx.
In the HERO study (https://www.sciencedirect.com/science/article/pii/S2588931123002900) comparing Orgovyx to Lupron. in addition to other factors affecting T recovery, “….Men ≤65 yr and those with baseline testosterone greater than the median had a higher incident rate of testosterone recovery…..”
This 2024 study discusses it: https://pubmed.ncbi.nlm.nih.gov/38552845/
This 2008 study discusses it: https://pubmed.ncbi.nlm.nih.gov/18279929/
The full results of that HERO study comparing Orgovyx to Lupron should be of interest to anyone interested in comparing T recovery.