Seven years is a long time on ADT. I would think that the guidelines for testosterone return get somewhat fuzzy after so long.

I’ve read that older age can impact the rebound of testosterone as well. I’ve read that with age, the testosterone sometimes might never rebounds. So, age + time on ADT is not always a good combination.

I was on Eligard for six months (two 3-month injections in April and July 2021) along with my 28 proton radiation treatments (19 April-28 May 2021). My testosterone level dropped as low as 3.0 ng/dL, and remained in the high-single/low-double digits the entire time the Eligard was in my system. (My PSA dropped to 0.008 ng/mL.) It took 4 months after the end of that second 3-month injection for my testosterone levels to return to normal. That’s a little more than the +50% time that I read about, but it was close enough……

I experienced no testicular issues, but had significant muscle atrophy and loss of strength.

In January 2022, I recall telling my wife that I thought the Eligard was wearing off because I was beginning to lift heavier weights at the gym. Since I wasn’t due for another “official” bloodwork for another couple of months, I self-ordered another PSA & testosterone test (out of curiosity), and those came back as 0.13 ng/mL & 403.0 ng/dL, respectively - meaning that everything was going exactly as expected (that is, PSA was staying low and testosterone was on its way up). The muscle mass, and strength all slowly returned.

Testosterone levels have long been back to normal and PSA varies between 0.35-0.55. Most recent PSA was 0.476.